Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases bothdopamine and serotonin levels in nucleus accumbens of awake rats

The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1-one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant,entactogenic and hallucinogenic effects. The purpose of this study was to examine the effectsof acute administration of mephedrone on extracellular levels of dopamine (DA) andserotonin (5-HT) in the nucleus accumbens of awake rats and compare these effects to thoseinduced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine.

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